GLUTEN AND COELIAC SCREEN BLOOD TEST

This is a complex investigation that checks the necessary biomarkers for coeliac disease and body's reaction to gluten.

Total IgA - Total IgA quantifies overall Immunoglobulin A production in the body. In the context of coeliac screening, measuring Total IgA helps identify IgA deficiency, a condition in which the body either produces insufficient amounts of IgA or none at all. If you have an IgA deficiency, IgA-based coeliac tests may give falsely negative results, so this biomarker serves as an essential first step in accurate diagnostic evaluation.

Tissue Transglutaminase IgA (tTG-IgA) - Tissue Transglutaminase IgA is the primary and most specific serological marker for diagnosing coeliac disease. When people with coeliac disease consume gluten, their immune system produces antibodies against tissue transglutaminase, an enzyme involved in the post-translational modification of gluten peptides. Elevated tTG-IgA levels strongly indicate an immune-mediated reaction consistent with coeliac pathology, making it a cornerstone of diagnostic testing.

Gliadin IgA - Gliadin is one of the main protein components of gluten. Gliadin IgA antibodies are another measure of the immune system’s reaction to ingested gluten. Though Gliadin IgA can be useful, particularly in evaluating younger children, it is generally considered less specific than tTG-IgA for coeliac disease. Nonetheless, it can provide additional clinical insights when combined with other biomarkers.

Gliadin IgG - Gliadin IgG testing is often used alongside or as an alternative to Gliadin IgA in people who have confirmed or suspected IgA deficiency. In such cases, IgA-based tests may not be accurate, so testing for IgG antibodies against gliadin can help detect an ongoing immune response to gluten. Elevated Gliadin IgG levels may warrant further diagnostic steps for coeliac disease or other gluten-related disorders.

4 BIOMARKERS

GLUTEN AND COELIAC SCREENS

- Total IgA
- Tissue Transglutaminase IgA
- Gliadin IgA
- Gliadin IgG
UPGRADE

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